This special issue has followed up the 1st International Conference on Supply Chains held at October 1-2, 2010, in Katerini, Greece. More than 400 attendances, 100 presenters of research papers, and 6 keynote invited speakers, have participated in the 2-Days Conference that it has been embraced positively by the academic and business community. 80 research papers of them went into the review process (20 had to be either rejected at an early stage, because of a lack of relevancy to the conference topics or presented as posters). Then, each of the 80 papers was reviewed by a minimum of two reviewers. In total 160 reviews were collected in a double-blind review process. Finally, 10 papers were accepted and submitted for the final review process in order to be published at the OSCM International Journal.