The confluence of artificial intelligence (AI), autonomous cyber-physical systems (CPS), and sophisticated decision-making technologies represents more than incremental advancement in operations and supply chain management (OSCM)-it signals a fundamental paradigm shift that redefines how organizations create, deliver, and capture value in interconnected global networks. This transformation occurs at a pivotal moment when supply chain vulnerabilities exposed by recent global disruptions intersect with unprecedented technological capabilities. This special issue advances the OSCM research frontier through methodologically diverse investigations that collectively reveal three critical insights regarding the complex interplay within technology-enabled supply chain transformation. As guest editors, we believe this collection establishes new foundations and provides actionable guidance for the OSCM community. The research demonstrates that the future of supply chain management lies in orchestrating intelligent systems that amplify human capabilities while remaining grounded in organizational realities. We extend our gratitude to the authors, reviewers, and editorial team whose contributions made this collection possible.